Updates

April 22, 2019April 22, 2019
Rituximab Safe, Eases Skin Fibrosis in Systemic Sclerosis Patients, Study Suggests

Rituximab, an immunosuppressant antibody, alleviates skin fibrosis in patients with systemic sclerosis (SSc) and was also found to be generally safe, according to ... Read more
April 17, 2019April 17, 2019
Epigenetic Changes May Be Involved in Scleroderma Development, Study Says

Epigenetic changes — chemical modifications in DNA that affect gene expression (the process by which information within a gene gives rise to a functional ... Read more
April 15, 2019April 15, 2019
Star-studded Scleroderma Fundraiser ‘Cool Comedy – Hot Cuisine’ Set for April 25 in Beverly Hills

While finding a cure for scleroderma is serious business, the Scleroderma Research Foundation (SRF) mixes in comedy, show business, and good food at its celebrity-filled ... Read more
April 12, 2019April 12, 2019
Estradiol Could Be Key Therapeutic Target Against dcSSc, Study Suggests

Men older than 50 with diffuse cutaneous systemic sclerosis (dcSSc) have higher levels of estradiol, an active form of estrogen, in their blood compared ... Read more
April 9, 2019
Blood Test May Help Identify Systemic Sclerosis Patients at Risk of Poor Outcomes, Study Suggests

A simple routine blood test that measures the levels of immune cells called monocytes may help identify patients with fibrotic diseases, including systemic sclerosis, ... Read more

Columns, Scleroderma and the Ordinary Girl

Times of Stress Demand that I Create Space to Heal
April 9, 2019April 5, 2019
These last few weeks have been some of the worst I can remember. Not ...
News

TLY012 Fares Well in Mouse Model as Potential Treatment for Scleroderma
April 8, 2019
TLY012, a lab-made equivalent of a natural protein called TRAIL, can reverse skin fibrosis ...
News

52% of SSc Patients Have Autoantibodies Years Before Diagnosis, Study Finds
April 3, 2019April 3, 2019
Increased levels of specific antibodies that can attack the host’s own tissues may be ...
Columns, Scleroderma and the Ordinary Girl

Surviving Scleroderma Amid Chaos in My Hometown
April 2, 2019March 29, 2019
Two weeks ago my world was rocked by the mass terrorist shooting in two ...
News

Skin Fibrosis Scores Can Be Surrogate Marker for dcSSc Severity, Study Finds
April 1, 2019April 1, 2019
Progressive skin fibrosis within one year increases the risk of lung function decline and mortality ...
News

Systemic Sclerosis Not Linked to Problems with Exocrine Pancreas, Which Carries Malnutrition Risk, Study Finds
March 29, 2019March 29, 2019
Systemic sclerosis (SSc) is not associated with clinically significant exocrine pancreatic dysfunction, a condition ...

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ANCA Autoantibodies Associated with Worse Prognosis for Scleroderma Patients, Study Reports
March 28, 2019March 28, 2019
Scleroderma patients with ANCA autoantibodies have a higher prevalence of interstitial lung disease (ILD) ...
EHP-101 Prevents Blood Vessel Damage, Reduces Fibrosis and Inflammation, Mouse Study Determines
March 26, 2019March 26, 2019
Emerald Health Pharmaceuticals’ cannabis-derived therapy, EHP-101, eased the symptoms of systemic sclerosis by preventing ...
Nintedanib Submitted for Regulatory Approval to Treat SSc-ILD in US and Europe
March 21, 2019March 21, 2019
Poor SSc-PH-ILD Prognosis May be Linked to Pulmonary Veno-occlusive Disease
March 19, 2019March 19, 2019
Brexit Could ‘Devastate’ UK Rare Disease Patients, Experts Warn
March 14, 2019March 14, 2019
Moral Dilemmas Complicate Treatment of Rare Diseases, Says Israeli Bioethicist
March 13, 2019March 13, 2019

First Patient Dosed in Ongoing Trial to Test AVID200 for Diffuse Cutaneous Systemic Sclerosis
March 12, 2019March 12, 2019
The first patient with diffuse cutaneous systemic sclerosis (SSc) has been given the investigational therapy ...
Exercising with Scleroderma My Way
March 12, 2019March 11, 2019
NIH Rare Disease Day Highlights Joint Networks Advancing Array of Research
March 5, 2019
SSc Patients’ Health-related Quality of Life Worse Than Those With Other Rheumatoid Diseases, Study Finds
February 28, 2019February 28, 2019

Staying One Step Ahead of Scleroderma
February 26, 2019February 22, 2019
Sometimes when I’m sitting in my recliner thinking about the meaning of life, I ...
Study Results Prompt Inventiva to End Development of Lanifibranor for Scleroderma
February 26, 2019February 26, 2019
WODC 2019 Organizers Expect 1,200 to Attend Rare Disease Conference in April
February 25, 2019February 25, 2019

News

Vienna to Host RARE2019 Meeting on Rare Diseases
February 22, 2019February 22, 2019
About 100 scientists, researchers, pharmaceutical executives, and others will converge on Austria’s capital city ...
News

Enzyme in Skin and Blood Vessel Cells May Offer Way of Treating Scleroderma, Study Reports
February 21, 2019February 21, 2019
The enzyme EZH2 is present in higher-than-normal levels in fibroblasts and endothelial cells from ...
Columns, Scleroderma and the Ordinary Girl

My Trauma-related Scleroderma Puzzle: How Does It Fit Together?
February 19, 2019February 18, 2019
Burnout is often used to describe what can happen to those living with constant ...
News

Systemic Sclerosis Patients Have Deregulated Levels of Skin Microorganisms, Study Shows
February 19, 2019February 19, 2019
Deregulation of the microorganisms that naturally populate the skin is associated with increased inflammation ...
News

Arrhythmia Linked to Fibrosis in Asymptomatic Patients with Scleroderma, Study Suggests
February 14, 2019February 14, 2019
A device designed to continuously record heart rhythm showed that asymptomatic patients with scleroderma have ...
Columns, Scleroderma and the Ordinary Girl

Welcoming Kindness Creates Space for Healing
February 12, 2019February 8, 2019
I had to travel to another part of the country last week. The outing ...
News

Inhibiting PU.1 Protein May Hold Promise for Treating Fibrotic Diseases, Including Systemic Sclerosis
February 12, 2019February 12, 2019
Inhibiting the protein PU.1 has potential as a therapy to treat multiple fibrotic diseases, ...
News

Patients, Family and Friends to Take Part in Variety of Rare Disease Day Events Worldwide
February 11, 2019February 11, 2019
Scores of events are afoot worldwide to mark Feb. 28, Rare Disease Day 2019. The activities ...
News

sE-selectin, sIL-2R Levels Are Potential Markers of Localized Scleroderma Activity
February 7, 2019February 7, 2019
Serum levels of E-selectin (sE-selectin) and soluble interleukin-2 receptor (sIL-2R) are potential prognostic markers ...
Columns, Scleroderma and the Ordinary Girl

I’m Bursting the Scleroderma Boredom Bubble
February 5, 2019February 1, 2019
The chronically unwell face plenty of daily challenges, some big and some small. But ...
News

SSc Patients Show Improvements After CD34-selected Stem Cell Transplant, Study Reports
February 5, 2019February 5, 2019
Systemic sclerosis (SSc) patients showed reduced skin thickness and improved lung function after a ...
News

Clinical Signs of Interstitial Lung Disease in Systemic Sclerosis Patients Identified, Study Reports
January 31, 2019January 31, 2019
Certain clinical characteristics that researchers suggest could be potentially useful indicators of interstitial lung ...

March 16, 2018March 16, 2018

iBio Selects Fusion Protein as Lead Candidate for New Scleroderma Treatment

News

iBio has selected a lead scleroderma treatment candidate — a molecule it calls the E4-Fc fusion protein. The company plans to continue developing it, with a goal of moving it in clinical trials in people. It also hopes ... Read more

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