Updates

January 20, 2020January 20, 2020
Variant in STAT4 Gene Protects Patients Against SSc-ILD Development, Study Suggests

A specific variant in the STAT4 gene protects people with scleroderma against the development of interstitial lung disease (ILD), a new study in patients of European descent ... Read more
January 17, 2020January 17, 2020
Rule Out Bowel Perforation Early in Scleroderma Patients with Abdominal Symptoms, Study Advises

Early detection of bowel perforation in scleroderma patients who are experiencing abdominal symptoms may be lifesaving, according to a case report. Researchers emphasize that it is ... Read more
January 15, 2020January 15, 2020
FDA Paves Way for Phase 2 Testing of EHP-101 for Scleroderma

The U.S. Food and Drug Administration (FDA) has cleared an application from Emerald Health Pharmaceuticals that paves the way to begin a Phase 2 ... Read more
January 13, 2020January 13, 2020
Combined Imaging Approach Can Help Diagnose Scleroderma Earlier, Study Indicates

The combination of three imaging techniques can provide a better understanding of structural and functional skin changes in the fingers, leading to an earlier ... Read more
January 8, 2020January 8, 2020
Autoantibodies Linked to Genetic and Environmental Factors in Scleroderma, Study Finds

Researchers have zeroed in on autoantibodies that may be linked to distinct human leukocyte antigen (HLA) genes and environmental factors, something that could help ... Read more

News

Small Molecule Holds Promise Against Fibrosis in Scleroderma, Other Disorders, Study Suggests
January 6, 2020January 6, 2020
Using a new stem cell-based model, researchers have discovered a molecule that can reverse ...
News

IVIG Therapy Can Help Reduce Corticosteroid Dosage for Scleroderma-associated Myopathy, Study Finds
January 3, 2020January 3, 2020
Intravenous antibodies can be used as add-on therapy to reduce the dosage of corticosteroids ...
News

Servier and UCL Partner to Battle Scleroderma and Lupus
December 20, 2019December 20, 2019
A new collaboration between Servier Pharmaceuticals and University College London (UCL) seeks to speed the ...
News

Global Genes Awards Nearly $200K to Scleroderma Foundation, Other Rare Disease Organizations
December 18, 2019December 18, 2019
The Scleroderma Foundation is among the recipients of nearly $200,000 in awards through the 2020 ...
News

Cedars-Sinai Receives $20M Donation to Create Kao Autoimmunity Institute and Scleroderma Program
December 16, 2019December 16, 2019
Cedars-Sinai has received a $20-million donation from Dr. and Mrs. Min H. Kao and ...
News

Similar Symptoms Found in Scleroderma Patients in the U.S., Regardless of Their Immunosuppressant Use, Study Finds
December 13, 2019December 13, 2019
About a third of people diagnosed with scleroderma in the U.S. were prescribed immunosuppressive ...

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Cantargia Starts Development of CAN10 Antibody for Scleroderma, Myocarditis
December 11, 2019December 11, 2019
Cantargia will start the preclinical development of a new antibody, called CAN10, intended to ...
Galapagos Completes Enrollment in Phase 2a Trial Testing GLPG1690 in Diffuse Cutaneous Scleroderma
December 9, 2019December 9, 2019
A Phase 2a clinical trial designed to test Galapagos‘ investigational oral therapy GLPG1690 in ...
HHS Secretary Alex Azar Touts White House Efforts to Cure Rare Diseases
December 6, 2019
Bob Saget to Host Annual Cool Comedy – Hot Cuisine Event to Benefit Scleroderma Research Foundation
December 6, 2019December 6, 2019
Antibody CD45-ADC Shows Potential to Treat Scleroderma and Other Diseases in Mice, Study Shows
December 4, 2019December 4, 2019
Health Canada Approves Ofev to Help Preserve Lung Health in People with SSc-ILD
December 2, 2019December 2, 2019

Cardiopulmonary Exercise Testing May Help Detect PAH in Scleroderma Patients, Study Suggests
November 27, 2019November 27, 2019
Cardiopulmonary exercise testing (CPET), along with an algorithm that considers both lung and heart ...
Advanced Ultrasound of Skin May Best Determine Scleroderma Activity and Progression, Study Suggests
November 22, 2019November 22, 2019
Lenabasum Shows Sustained Efficacy in Patients with Diffuse Cutaneous Scleroderma, Extension Study Finds
November 20, 2019November 20, 2019
Rare Disease Film Festival Highlights Patient and Researcher Unity
November 15, 2019November 16, 2019

Black Patients with Scleroderma Experience Faster Disease Progression and Higher Mortality than Whites and Asians, Study Finds
November 13, 2019November 13, 2019
Black patients with scleroderma experience faster disease progression, higher prevalence of diffuse skin involvement, ...
Ofev Slows Lung Function Decline in SSc-ILD Patients, Analysis of Phase 3 Study Shows
November 11, 2019
Younger Age, Thicker Skin at Scleroderma Onset Increase Risk of Heart Muscle Inflammation, Study Suggests
November 6, 2019November 6, 2019

News

Letairis Fails To Lower PH, But Improves Cardiac Function, Blood Flow in Scleroderma, Phase 2 Trial Shows
November 4, 2019November 4, 2019
Treatment with Letairis (ambrisentan) failed to significantly reduce pulmonary blood pressure at rest and ...
News

Skin Lesions Develop Soon After Onset of Raynaud’s Phenomenon, 10-year Follow-up Study Reports
November 4, 2019November 4, 2019
Most people with scleroderma develop skin lesions within one year after the onset of ...
News

Digital Ulcers Strongly Affect Pain and Daily Life in Scleroderma Patients, Spanish Study Finds
October 30, 2019October 30, 2019
Digital ulcers (DUs) aggravate hand disability, limit daily activities, and affect work productivity in ...
News

Real-World Data Show Safety, Efficacy of Opsumit for PAH Due to Scleroderma
October 28, 2019October 28, 2019
Real-world clinical data support the use of Opsumit (macitentan) to treat people with pulmonary ...
News

IFNL3 Gene Variant Linked to High Risk of PF in Scleroderma Patients, Study Finds
October 25, 2019October 25, 2019
A recently discovered variant of the IFNL3 gene increases the risk of pulmonary fibrosis ...
News

Wide Range of Eye Complications Associated with Scleroderma, Study Shows
October 23, 2019October 23, 2019
People with systemic sclerosis (SSc) show a wide range of eye complications, with dry ...
News

Treating Scleroderma When Neuromyelitis Optica Also Present ‘Challenging,’ Case Study Reports
October 21, 2019October 21, 2019
People with scleroderma can develop autoimmune diseases like neuromyelitis optica (NMO), a condition that ...
News

Long-term Adempas May Heal Digital Ulcers in Scleroderma Patients, Phase 2 Study Finds
October 18, 2019October 18, 2019
Patients with scleroderma may need longer-term treatment with Adempas (riociguat) to heal their digital ...
News

One-Year Cytoxan Treatment Improves Lung Function in Scleroderma-ILD Patients, Trials Show
October 16, 2019October 16, 2019
Treatment for one year with the immunosuppressant Cytoxan (cyclophosphamide) improves lung function in scleroderma patients with ...
News

Early Immunosuppressive Treatment May Prevent ILD Progression in SSc Patients, Study Suggests
October 14, 2019October 14, 2019
Immunosuppressive treatment of early-stage interstitial lung disease (ILD) in people with systemic sclerosis may ...
News

Ofev Granted FDA Breakthrough Therapy Status for Progressive Interstitial Lung Disease Treatment
October 11, 2019October 11, 2019
The U.S. Food and Drug Administration (FDA) has granted breakthrough therapy designation to Ofev (nintedanib) as a potential therapy for ...
News

Experts Issue Recommendations for Managing Juvenile Localized Scleroderma
October 9, 2019October 9, 2019
Referral to specialized centers, focusing on skin lesions as well as joint and neurological ...

March 16, 2018March 16, 2018

iBio Selects Fusion Protein as Lead Candidate for New Scleroderma Treatment

News

iBio has selected a lead scleroderma treatment candidate — a molecule it calls the E4-Fc fusion protein. The company plans to continue developing it, with a goal of moving it in clinical trials in people. It also hopes ... Read more

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