Updates

April 6, 2020April 6, 2020
Phase 2 Trial to Test Cannabidiol-derived EHP-101 in Diffuse Cutaneous Scleroderma

Emerald Health Pharmaceuticals has launched a clinical trial evaluating EHP-101, its investigational cannabidiol-derived therapy, in adults with diffuse cutaneous systemic sclerosis (dcSSc). “This ... Read more
March 30, 2020March 30, 2020
Canada Clears EHP-101, Possible Cannabidiol-derived Treatment

The active ingredient in EHP-101 — known as VCE-004.8, derived from synthetic cannabidiol — is not classified as a controlled substance under Canada’s Controlled Drug and ... Read more
March 27, 2020March 27, 2020
NORD Partners with ‘Sing Me a Story’ for July 18–20 Living Rare Forum

The Living Rare, Living Stronger Patient and Family Forum, originally set for May 14–16 in Cleveland, Ohio, has been postponed until July 18–20 because ... Read more
March 25, 2020March 25, 2020
Global Rare Disease Group’s Focus: 1,000 New Therapies by 2027, Despite COVID-19

Even with the coronavirus pandemic ravaging Europe and much of the world, patient advocate Lucia Monaco, PhD, of Italy remains confident that the Paris-based ... Read more
March 23, 2020March 23, 2020
Subset of Immune B-Cells Linked to Vascular Damage in Some Patients, Study Suggests

Levels of a subtype of immune B-cells in the blood are increased in some people with scleroderma and associated with lower respiratory function, higher ... Read more

News

Vitamin E, Pentoxifylline and TheraBite System Ease Lockjaw, Small Study Suggests
March 20, 2020March 20, 2020
Using vitamin E, pentoxifylline, and the TheraBite Jaw Motion Rehabilitation System may help reduce ...
News

Emerald Health Awarded 6 Patents for Potential Cannabis Treatments
March 18, 2020March 18, 2020
Emerald Health Pharmaceuticals (EHP), the company developing the synthetic cannabis-derived EHP-101 as a treatment ...
News

Blood Levels of Fibrotic Protein Tied to SSc-ILD, May Serve as Biomarker
March 16, 2020March 27, 2020
Higher-than-normal blood levels of squamous cell carcinoma antigen 1 (SCCA1), a pro-fibrotic protein, are ...
News

Heart, Kidney Imaging Could Detect Fibrosis in Scleroderma, Study Finds
March 13, 2020March 13, 2020
Heart and kidney imaging may help detect fibrosis, or scarring, in asymptomatic people with scleroderma, ...
News

New Ultrasound Technique Detects Early Skin Changes in Scleroderma, Study Suggests
March 11, 2020March 11, 2020
A new non-invasive ultrasound imaging technique can detect changes in skin elasticity that are ...
News

Pediatric Rare Disease Therapies Increase, But Most Repurposed, Study Finds
March 10, 2020March 10, 2020
The number of treatments for children with rare diseases has grown over the past decade, ...

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Tracleer Seen to Ease Skin Symptoms in Small Scleroderma Study
March 9, 2020March 9, 2020
One year of treatment with Tracleer (bosentan) significantly reduces the severity of patient-reported skin ...
Cannabidiol Therapy, EHP-101, Put on Fast Track by FDA
March 6, 2020April 6, 2020
EHP-101, an oral therapy based on cannabidiol (CBD), has been placed on fast track development ...
Video: BioNews’ Social Media Campaign Highlights #WhatMakesMeRare
March 5, 2020March 5, 2020
CHMP Favors EU Approval of Ofev to Preserve Lung Function in SSc-ILD
March 4, 2020March 4, 2020
Elsevier Opens Books, Review Articles to Rare Disease Researchers Starting Feb. 29
March 3, 2020March 3, 2020
Panel Develops SSc-ILD Diagnosis, Management Guidelines
March 2, 2020March 2, 2020

Inhibiting Key Protein May Ease Lung Scarring in Systemic Scleroderma, Study Suggests
February 28, 2020February 28, 2020
Inhibiting a protein known as KLHL42 may ease lung fibrosis (scarring) associated with systemic ...
Advice on Starting Nonprofit Groups for Rare and Other Diseases Focus of NORD Webinar
February 27, 2020February 27, 2020
Model Identifies Five Skin-Score Classes to Predict Systemic Sclerosis Progression
February 26, 2020February 26, 2020
Autoantibodies Better Predictors of Scleroderma Prognosis Than Disease Overlap, Study Finds
February 24, 2020February 24, 2020

Study of ‘Pre-Ulcer’ Stage May Inform Treatment of Digital Ulcers in Scleroderma
February 21, 2020February 21, 2020
A pre-clinical stage preceding the development of digital ulcers could provide a window of opportunity ...
Patients, Supporters Worldwide Recognizing Rare Disease Day 2020
February 20, 2020March 3, 2020
Molecule Drives Activation of Key Cells in Scleroderma, Study Reports
February 19, 2020February 19, 2020

News

Scientists Identify Common Genetic Ground Between Scleroderma and Crohn’s
February 17, 2020February 24, 2020
Changes in four DNA spots influence the risk of developing both scleroderma and Crohn’s ...
News

Privigen Granted FDA’s Organ Drug Status to Treat Scleroderma as Phase 2 Trial Continues Enrolling Patients
February 14, 2020February 18, 2020
Privigen — an approved therapy for a range of immune-related conditions — has been ...
News

New Questionnaire Measures Effect of Digital Ulcers on Hand Function
February 12, 2020February 12, 2020
Researchers have come up with a new, patient-reported questionnaire to measure the impact of ...
News

FDA Efforts to Bring Patients into Treatment Decisions Focus of NORD Webinar
February 11, 2020February 11, 2020
The U.S. Food and Drug Administration (FDA), a vast government bureaucracy, employs about 17,500 ...
News

Study Finds Elevated Levels of Immunosuppressive HLA-G Protein in the Immune Cells of Scleroderma and Lupus Patients
February 10, 2020February 10, 2020
The levels of an immunosuppressive protein called human leukocyte antigen G (HLA-G) are significantly ...
News

Restoring CCN3 Protein in Skin Could Improve Growth of Blood Vessels in Scleroderma, Study Suggests
February 7, 2020February 7, 2020
Restoring the levels of a protein known as CCN3 in the skin of people ...
News

With Post-Brexit Move to Amsterdam Complete, EMA Renews Rare Disease Focus
February 6, 2020February 6, 2020
The gleaming new Dutch headquarters of the European Medicines Agency (EMA), fronting Domenico Scarlattilaan ...
News

Impaired Swallowing Linked to Depression, Lower Quality of Life in Scleroderma, Study Finds
February 5, 2020February 5, 2020
Swallowing trouble in people with scleroderma is associated with lower quality of life and ...
News

Immune Dendritic Cells are Potential Therapeutic Target in Scleroderma, Mouse Study Suggests
February 3, 2020February 3, 2020
Immune players known as dendritic cells play a key role in scleroderma development in the ...
News

Localized Scleroderma Affects Quality of Life in Children, Study Finds
January 31, 2020January 31, 2020
Localized scleroderma affects health-related quality of life (HRQoL) in young people, causing joint and muscle ...
News

Younger Age at Scleroderma Onset, Being Male Linked to Digital Ulcers, Study Reports
January 27, 2020January 28, 2020
Scleroderma patients who develop digital ulcers are more likely to be younger at disease ...
News

Tests with Hand Function Tasks Better for Assessing Scleroderma Progression, Treatment Response, Study Finds
January 24, 2020January 29, 2020
Women with scleroderma take longer to perform daily living tasks, especially those that require ...

March 16, 2018March 16, 2018

iBio Selects Fusion Protein as Lead Candidate for New Scleroderma Treatment

News

iBio has selected a lead scleroderma treatment candidate — a molecule it calls the E4-Fc fusion protein. The company plans to continue developing it, with a goal of moving it in clinical trials in people. It also hopes ... Read more

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