Updates

December 13, 2019December 13, 2019
Similar Symptoms Found in Scleroderma Patients in the U.S., Regardless of Their Immunosuppressant Use, Study Finds

About a third of people diagnosed with scleroderma in the U.S. were prescribed immunosuppressive therapies in the first year after their diagnosis, but ... Read more
December 11, 2019December 11, 2019
Cantargia Starts Development of CAN10 Antibody for Scleroderma, Myocarditis

Cantargia will start the preclinical development of a new antibody, called CAN10, intended to treat people with scleroderma and myocarditis. The company aims to ... Read more
December 9, 2019December 9, 2019
Galapagos Completes Enrollment in Phase 2a Trial Testing GLPG1690 in Diffuse Cutaneous Scleroderma

A Phase 2a clinical trial designed to test Galapagos‘ investigational oral therapy GLPG1690 in people with diffuse cutaneous scleroderma has completed enrolling participants, ... Read more
December 6, 2019
HHS Secretary Alex Azar Touts White House Efforts to Cure Rare Diseases

Despite skyrocketing healthcare costs, President Trump is committed to protecting the 30 million or so Americans with rare diseases and ensuring timely, affordable access ... Read more
December 6, 2019December 6, 2019
Bob Saget to Host Annual Cool Comedy – Hot Cuisine Event to Benefit Scleroderma Research Foundation

Bob Saget will host the 42nd annual “Cool Comedy — Hot Cuisine” benefit of the Scleroderma Research Foundation (SRF) on Tuesday, Dec. 10. Saget, ... Read more

News

Antibody CD45-ADC Shows Potential to Treat Scleroderma and Other Diseases in Mice, Study Shows
December 4, 2019December 4, 2019
A single dose of an engineered antibody known as CD45-ADC can effectively eliminate disease-causing ...
News

Health Canada Approves Ofev to Help Preserve Lung Health in People with SSc-ILD
December 2, 2019December 2, 2019
Health Canada has approved Ofev (nintedanib) as a treatment to slow the decline of pulmonary function ...
News

Cardiopulmonary Exercise Testing May Help Detect PAH in Scleroderma Patients, Study Suggests
November 27, 2019November 27, 2019
Cardiopulmonary exercise testing (CPET), along with an algorithm that considers both lung and heart ...
News

Advanced Ultrasound of Skin May Best Determine Scleroderma Activity and Progression, Study Suggests
November 22, 2019November 22, 2019
An advanced imaging technique, called ultra-high-frequency ultrasound (UHF-US), provides detailed information of all skin ...
News

Lenabasum Shows Sustained Efficacy in Patients with Diffuse Cutaneous Scleroderma, Extension Study Finds
November 20, 2019November 20, 2019
People with diffuse cutaneous scleroderma (dcSSc) being treated with lenabasum continue to show improvement ...
News

Rare Disease Film Festival Highlights Patient and Researcher Unity
November 15, 2019November 16, 2019
Rare disease-themed videos glowed on a large screen before an audience of people in ...

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Black Patients with Scleroderma Experience Faster Disease Progression and Higher Mortality than Whites and Asians, Study Finds
November 13, 2019November 13, 2019
Black patients with scleroderma experience faster disease progression, higher prevalence of diffuse skin involvement, ...
Ofev Slows Lung Function Decline in SSc-ILD Patients, Analysis of Phase 3 Study Shows
November 11, 2019
Treatment with Ofev (nintedanib) slows the rate of lung function decline in people with autoimmune-related ...
Younger Age, Thicker Skin at Scleroderma Onset Increase Risk of Heart Muscle Inflammation, Study Suggests
November 6, 2019November 6, 2019
Letairis Fails To Lower PH, But Improves Cardiac Function, Blood Flow in Scleroderma, Phase 2 Trial Shows
November 4, 2019November 4, 2019
Skin Lesions Develop Soon After Onset of Raynaud’s Phenomenon, 10-year Follow-up Study Reports
November 4, 2019November 4, 2019
Digital Ulcers Strongly Affect Pain and Daily Life in Scleroderma Patients, Spanish Study Finds
October 30, 2019October 30, 2019

Real-World Data Show Safety, Efficacy of Opsumit for PAH Due to Scleroderma
October 28, 2019October 28, 2019
Real-world clinical data support the use of Opsumit (macitentan) to treat people with pulmonary ...
IFNL3 Gene Variant Linked to High Risk of PF in Scleroderma Patients, Study Finds
October 25, 2019October 25, 2019
Wide Range of Eye Complications Associated with Scleroderma, Study Shows
October 23, 2019October 23, 2019
Treating Scleroderma When Neuromyelitis Optica Also Present ‘Challenging,’ Case Study Reports
October 21, 2019October 21, 2019

Long-term Adempas May Heal Digital Ulcers in Scleroderma Patients, Phase 2 Study Finds
October 18, 2019October 18, 2019
Patients with scleroderma may need longer-term treatment with Adempas (riociguat) to heal their digital ...
One-Year Cytoxan Treatment Improves Lung Function in Scleroderma-ILD Patients, Trials Show
October 16, 2019October 16, 2019
Early Immunosuppressive Treatment May Prevent ILD Progression in SSc Patients, Study Suggests
October 14, 2019October 14, 2019

News

Ofev Granted FDA Breakthrough Therapy Status for Progressive Interstitial Lung Disease Treatment
October 11, 2019October 11, 2019
The U.S. Food and Drug Administration (FDA) has granted breakthrough therapy designation to Ofev (nintedanib) as a potential therapy for ...
News

Experts Issue Recommendations for Managing Juvenile Localized Scleroderma
October 9, 2019October 9, 2019
Referral to specialized centers, focusing on skin lesions as well as joint and neurological ...
Columns, Scleroderma and the Ordinary Girl

With Scleroderma, Exercise Comes at a Cost
October 8, 2019October 4, 2019
My cardiologist has given me the OK to go back to the gym. I’ve ...
News

Phase 2 Study of Bermekimab in Treating Scleroderma Enrolls 1st Patient
October 7, 2019October 7, 2019
The first person has been enrolled in a clinical trial evaluating the investigational therapy bermekimab ...
News

Estrogen Blocks Profibrotic Signals Driving Scleroderma, Study Suggests
October 4, 2019October 4, 2019
Blocking the activity of estrogen may worsen skin fibrosis in people with scleroderma, according ...
News

Raynaud’s Association Joins October Awareness Campaign, Notes Scleroderma Link
October 2, 2019October 2, 2019
Raynaud’s Association is launching several activities during October to raise awareness about Raynaud’s phenomenon, ...
Columns, Scleroderma and the Ordinary Girl

Finding the Glimmer of Gold Amid the Sludge of Scleroderma
October 1, 2019September 27, 2019
It has been a long few weeks of dealing with recurrent benign paroxysmal positional ...
News

Modified Inflammatory Protein May Help Reverse Fibrosis in Scleroderma, Mouse Study Suggests
September 30, 2019September 30, 2019
A modified version of the inflammatory protein TRAIL might be able to reverse fibrosis ...
News

NORD 2019 Rare Disease Summit Set for Oct. 21-22 in Washington, DC
September 27, 2019September 27, 2019
Next month’s annual conference of the National Organization for Rare Disorders (NORD) in Washington, ...
News

Processa Enters Agreement to Develop HT-100 as Possible Fibrotic Disease Treatment
September 23, 2019September 23, 2019
Processa Pharmaceuticals announced it has entered into a global licensing agreement with Akashi Therapeutics ...
News

FDA Approves Ofev to Slow Lung Function Decline in SSc-ILD Patients
September 10, 2019September 10, 2019
The U.S. Food and Drug Administration (FDA) has approved Ofev (nintedanib) as the first therapy to ...
Columns, Scleroderma and the Ordinary Girl

Grappling with My Identity as a Scleroderma Patient
September 10, 2019September 5, 2019
It’s been an eventful couple of weeks. I am currently dealing with several crises ...

March 16, 2018March 16, 2018

iBio Selects Fusion Protein as Lead Candidate for New Scleroderma Treatment

News

iBio has selected a lead scleroderma treatment candidate — a molecule it calls the E4-Fc fusion protein. The company plans to continue developing it, with a goal of moving it in clinical trials in people. It also hopes ... Read more

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